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Ascend Therapeutics Partners with Valeant Pharmaceuticals to promote Migranal® migraine product to OB/GYN physicians, October 2007

ALISO VIEJO, Calif., October 1, 2007

Valeant Pharmaceuticals International (NYSE:VRX) today announced that it has granted ASCEND Therapeutics exclusive rights to deploy ASCEND's 50-person specialty sales force to promote Valeant's Migranal® (dihydroergotamine mesylate, USP) Nasal Spray to more than 5,500 OB/GYNs in the United States. Valeant will continue to market Migranal to physicians outside the OB/GYN specialty area and retain all other responsibilities for the product.

"We are pleased to announce the promotion of Migranal to OB/GYNs with our partner ASCEND Therapeutics. Of the more than 65 million people worldwide who have experienced a migraine within the last 12 months, three-quarters of these patients are women. Migranal provides physicians with a valuable treatment option for patients with migraine headaches," said Wesley P. Wheeler, president, North America and Research and Development at Valeant.

"We are pleased to have the opportunity to promote a therapeutic option to treat a condition so common among women often in the early morning hours or during times of falling estrogen levels. Migranal provides significant value to women and to our women's health care franchise and will be integral as we continue to build and foster our specialty in the OB/GYN community," said Jay Bua, president of Ascend Therapeutics.

About Valeant

Valeant Pharmaceuticals International (NYSE:VRX) is a global specialty pharmaceutical company that develops, manufactures and markets a broad range of pharmaceutical products primarily in the areas of neurology, infectious disease and dermatology. More information about Valeant can be found at www.valeant.com.

About ASCEND

ASCEND Therapeutics is a biopharmaceutical company focused on the use of transdermal drug delivery technology to overcome therapeutic barriers and raise the standard of care for certain chronic conditions. For more information about ASCEND, you may visit the company's web site at www.ascendtherapeutics.com.
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